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Severe hypoglycemia is a probably life threatening condition that could cause seizures and lack of consciousness.<br><br>The lower in carbohydrate oxidation observed after four weeks of HA represents a crucial metabolic adaptation to support the enhancement of ventilatory thresholds. Enhanced muscle glycogen utilization efficiency ensures the less metabolic heat manufacturing and decrease core temperature during exercise. The decreased carbohydrate oxidation induced by the 4-week HA turns into a crucial phenotype for endurance runners; it can't only optimize thermoregulation but also improve aerobic capacity. However, limitations ought to be thought of on this research. First, the core temperature was monitored by the greenTEG CORE sensors constantly. While greenTEG sensors are effective in measuring surface temperature, precisely capturing core temperature, especially during excessive-intensity exercise, stays difficult. This problem could probably have an effect on the precision of interpreting physiological adaptation response to HA. Second, carbohydrate oxidation was calculated however not directly measured. Third, muscle glycogen utilization was not measured. In this study, the decrease in carbohydrate oxidation of trained runners throughout sub-maximum train within the heat induced by 4 weeks of heat acclimation indicates improved muscle glycogen utilization efficiency, supporting the enhancement of ventilatory thresholds and thermoregulatory adaptation, thereby improving aerobic capability within the heat.<br>