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Significantly enriched gene-metabolite networks were found linked to sarcomeric integrity, immune fitness, and  [https://yogicentral.science/wiki/User:HermineDeBoos9 Alpha Surge Male performance booster] oxidative stress response; all inhibited in space as per in silico prediction. A significant loss of mitochondrial DNA copy numbers in FLT mice underlined the energy deprivation associated with spaceflight-induced stress. This hypothesis was reinforced by the transcriptomic sequencing-metabolomics integrative analysis that showed inhibited networks related to protein,  [https://cameradb.review/wiki/Unlock_Your_Potential_With_Alpha_Surge_Male:_The_Ultimate_Performance_Booster buy Alpha Surge Male] lipid, and carbohydrate metabolism, and adenosine triphosphate (ATP) synthesis and hydrolysis. Finally, we discovered important upstream regulators, which could be targeted for next-generation therapeutic intervention for chronic disuse of the musculoskeletal system. 2020 The Authors. 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