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Chi-square tests and student’s t-test were used to determine the significance of differences among groups. CFA-negative patients with LE would also show a reduction in LE severity.METHODSOne hundred sixty-two Ghanaian participants with LE stage 1-5 (Dreyer) were randomized blockwise into 2 groups (CFA positive or negative) and allocated to 3 treatment arms of 6 weeks: (1) amoxicillin (1000 mg/d), (2) doxycycline (200 mg/d), or (3) placebo matching doxycycline. Parameters were assessed before treatment and after 3, 12, and 24 months.RESULTSDoxycycline-treated patients with LE stage 2-3 showed significant reductions in LE severity after 12 and 24 months, regardless of CFA status. 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