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In addition, some DOACs require twice-day by day dosing that,  [https://www.wakewiki.de/index.php?title=Monitoring_Blood-Brain_Barrier_Opening_In_Rats_With_A_Preclinical_Focused_Ultrasound_System BloodVitals experience] when in comparison with warfarin’s as soon as-per-day administration, could lead to extra missed doses. One vital concern of patients and physicians has been that there was no particular antidote for DOACs. This is no longer the case. In 2015 the FDA authorised idarucizumab (Praxbind®) for reversal of dabigatran (Pradaxa®). On May 4th 2018, FDA authorised andexanet alfa (AndexXa®) for the reversal of apixaban (Eliquis®) and rivaroxaban (Xarelto®). Ongoing studies are confirming its efficacy in reversing the opposite DOACs available on the market betrixaban (BevyxXa®) and edoxaban (Savaysa®) as well as the low molecular weight heparin enoxaparin (Lovenox®) and fondaparinux (Arixtra®). 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