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Examples of mild side effects include headache, nausea, fatigue, diarrhoea, abdominal pain, fever and rash. Most of the common side effects are mild and manageable, while some are severe, warranting stopping of therapy and moving to an alternate regimen. In these cases (or if individuals are unable to take first-line ARV treatment for another reason), the WHO recommends using a ritonavir-boosted protease inhibitor, plus two NRTIs for second-line treatment.<br><br><br> The WHO recommends the use of two NRTIs with one NNRTI in ART-naïve patients who meet the criteria for treatment. The World Health Organisation (WHO) recommends that all adults and adolescents with HIV commence ARV treatment when their CD4 cells counts reach or fall below 350 cells/mm3. HAART can suppress HIV replication and therefore prevent disease progression, reducing serious HIV-related illnesses and improving quality of life. 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The goals of treatment with HAART is to not only prolong the life of HIV-infected individuals (i.e. reduce the risk of death) but also to preserve and enhance the immune system.<br><br><br> These include drugs that interfere with HIV entry into human immune cells, known as entry inhibitors or fusion inhibitors. Another class of antiretrovirals drugs is also in development, known as the integrase inhibitors. Examples of integrase inhibitors includes raltegravir (e.g. Isentress) and elvitegravir. The first drugs in this class licensed for use were the fusion inhibitor enfuvirtide (e.g. Fuzeon), and a CCR5 antagonist, maraviroc (e.g. Celsentri). The newer ARV drugs use different mechanisms to arrest the HIV replication cycle. Many of these drugs are still in clinical trials and are not yet approved or recommended for human use. Some brands of Diclofenac include gelatin and should not be consumed by individuals who are allergic to bovine proteins. 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