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Electronic databases were searched using a [https://www.trainingzone.co.uk/search?search_api_views_fulltext=strategy%20combining strategy combining] the Cochrane Highly Sensitive Search Strategy for identifying randomized trials in MEDLINE: sensitivity-maximizing version (2008 revision) with selected MeSH terms and free text terms. We searched the Database of Abstracts of Reviews of Effectiveness (DARE) for related reviews. In addition, DULoxetine can cause seizures in susceptible patients, which may reduce the effectiveness of medications that are used to control seizures such as gabapentin. Even small doses can precipitate another reaction so desensitisation is contraindicated. Higher doses of beta-1 blockers lowered heart rate more than the lower doses, therefore are more likely to cause the common side effect of slowed heart rate. Higher dose beta-1 blockers lowered heart rate more than lower doses.<br><br><br> Most beta-1 blockers tested significantly lowered heart rate. 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