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Normally, a person inherits two copies of the gene that produces beta-globin, a protein needed to produce regular hemoglobin (hemoglobin A, genotype AA). An individual with sickle cell trait inherits one regular allele and one abnormal allele encoding hemoglobin S (hemoglobin genotype AS). Sickle cell trait is a hemoglobin genotype AS and is usually thought to be a benign situation. The sickle cell trait offers a survival benefit in opposition to malaria fatality over people with normal hemoglobin in areas where malaria is endemic. Some findings also show the reduction of the sickle-cell trait in those that retain much more fetal hemoglobin than normal in adulthood. Sickle cell trait describes a situation wherein an individual has one abnormal allele of the hemoglobin beta gene (is heterozygous), but doesn't show the extreme symptoms of sickle cell illness that occur in a one who has two copies of that allele (is homozygous). Taubenberger's autopsy outcomes confirmed that the soldier had had a sickle-cell disaster that contributed to his loss of life despite the fact that he had just one copy of the gene. That is a first-rate example of pure selection, evidenced by the truth that the geographical distribution of the gene for hemoglobin S and the distribution of malaria in Africa virtually overlap.



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