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2025年12月22日 (月) 22:58時点における最新版


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When a hundred Hz stimulus was imposed in optic nerves superfused with 10 mM glucose after a period of four min the CAP was maintained at its baseline degree (Brown et al., 2003). However the CAP fell when both the glycogen metabolism blocker isofagomine was added 20 min previous to the take a look at stimulus (Brown et al., 2005), or if 150 μM CIN or 20 mM D-lactate, the non-metabolizable isomer of L-lactate that's transported at the MCT but isn't metabolized, were added (Tekkok et al., 2005). These results add credence to the hypothesis that lactate is transferred to the axons beneath physiological situations (albeit extraordinarily excessive frequency firing) when superfused with normoglycemic concentrations of glucose. Thus optic nerve axons clearly show a degree of versatility depending upon instant energy expenditure and substrate requirement. In the presence of normoglycemic glucose (10 mM) blockade of lactate uptake into the axon by addition of CIN has no effect on the CAP (Brown et al., 2005), indicating that below such conditions there isn't any absolute requirement for lactate uptake into the axon.