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If glycolysis and gluconeogenesis had been concurrently energetic at excessive charges inside the identical cell, the net consequence could be the consumption of ATP and the era of heat, significantly on the irreversible steps of each pathways, with no productive metabolic final result. These two reactions, if occurring concurrently in reverse directions, lead to a futile cycle (also called a substrate cycle), leading to a wasteful dissipation of power. Allosteric regulation is speedy and reversible, occurring within milliseconds. In contrast, covalent modifications are usually triggered by extracellular signals, similar to hormones like insulin, glucagon, or epinephrine, and occur over seconds to minutes. Regulation through enzyme synthesis or degradation takes even longer, on the order of hours. 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