Sildenafil: MedlinePlus Dose Information

Universe pharmacokinetic data from patients in clinical trials also indicated a step-down in sildenafil citrate clearance when it was co-administered with CYP3A4 inhibitors (such as ketoconazole, erythromycin, or cimetidine) [see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS]. The potency of Viagra was evaluated in near studies victimization several judgement instruments. Deuce of the questions from the IIEF served as elementary learn endpoints; unconditional responses were elicited to questions astir (1) the power to achieve erections sufficient for sexual intercourse and (2) the sustenance of erections after incursion. The patient addressed both questions at the last bring down for the finally 4 weeks of the field of study. The potential flat responses to these questions were (0) no attempted intercourse, (1) ne'er or all but never, (2) a few times, (3) sometimes, (4) most times, and (5) about ever or always. Also assembled as theatrical role of the IIEF was information nigh other aspects of intimate function, including information on cavernous function, orgasm, desire, expiation with intercourse, and boilersuit sexual expiation. Intimate subroutine data were also recorded by patients in a time unit diary. In addition, patients were asked a globose efficaciousness head and an optional cooperator questionnaire was administered. In the firstly study, a individual oral examination back breaker of Viagra 100 mg or duplicate placebo was administered in a 2-historical period crossover voter pattern to 4 more often than not fit males with benignant endocrine hyperplasia (BPH). Pursuit at least 14 successive day-after-day doses of doxazosin, VIAGRA 100 mg or matching placebo was administered at the same time with doxazosin.
The physiologic chemical mechanism of hard-on of the penis involves tone ending of element oxide (NO) in the corpus cavernosum during intimate foreplay. NO then activates the enzyme guanylate cyclase, which results in increased levels of cyclic deoxyguanosine monophosphate (cGMP), producing fluid muscleman loosening in the principal sum cavernosum and allowing inflow of rake. However, since higher plasma levels English hawthorn gain theincidence of harmful reactions, a starting social disease of 25 mg should be consideredin elder subjects owed to the higher systemic photograph [see DOSAGE ANDADMINISTRATION]. Physicians should admonish patientsthat lengthened erections greater than 4 hours and priapism (terrible erectionsgreater than 6 hours in duration) take been reported infrequently since marketapproval of Viagra. In the result of an hard-on that persists yearner than 4hours, the patient should essay prompt checkup aid. If priapism is nottreated immediately, penial tissue paper damage and lasting red of authority mayresult [see WARNINGS AND PRECAUTIONS]. In a drug-do drugs interaction field of study sildenafil citrate 50 mg apt with alcoholic beverage 0.5 g/kg in which mean utmost bloodline inebriant levels of 0.08% was achieved, sildenafil citrate did non potentiate the hypotensive burden of alcohol in fit volunteers [see CLINICAL PHARMACOLOGY].
Maximum discovered plasm concentrations are reached inside 30 to 120 minutes (median value 60 minutes) of oral exam dosing in the fasted land. When Sildenafil is taken with a mellow fatten up meal, the pace of concentration is reduced, with a miserly holdup in T of 60 transactions and a hateful simplification in Cmax of 29%. The tight calm DoS loudness of distribution (Vss) for sildenafil citrate is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both close to 96% border to plasma proteins. Bingle unwritten doses of sildenafil citrate up to 100 mg produced no clinically relevant changes in the ECGs of convention virile volunteers.
Intimate action bum redact an superfluous tense on your heart, especially if your tenderness is already watery from a warmheartedness assail or core disease. Postulate your doc if your nub is fit enough to wield the supernumerary mental strain of having sexuality. Sildenafil citrate is absolved preponderantly by the CYP3A4 (Major route) and CYP2C9 (underage route) hepatic microsomal isoenzymes. The major circulating metabolite results from Ndesmethylation of sildenafil, and is itself farther metabolized. This metabolite has a PDE selectivity profile exchangeable to sildenafil citrate and an in vitro potentiality for PDE5 approximately 50% of the bring up do drugs. Plasma concentrations of this metabolite are about 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil’s pharmacologic personal effects. In cases of overdose, measure supportive measures should be adoptive as needed.
The prohibition of PDE5 in more or less of these tissues by Viagra Crataegus laevigata be the footing for the enhanced thrombocyte antiaggregatory action of NO ascertained in vitro, an suppression of blood platelet thrombus geological formation in vivo and peripheral device arterial-venous distention in vivo. Viagra is contraindicated in patients with a known hypersensitivity to sildenafil, as contained in Sildenafil and REVATIO, or whatsoever constituent of the pad of paper. Hypersensitivity reactions possess been reported, including blizzard and urtication [see ADVERSE REACTIONS]. There was no deadening offertility in rats minded Viagra up to 60 mg/kg/twenty-four hours for 36 years to femalesand 102 years to males, a acid producing an AUC valuate of Thomas More than 25 multiplication thehuman virile AUC. VIAGRA does non protect against sexually transmitted diseases, including HIV. Separate your health care supplier astir completely the medicines you take, including prescription medicine and over-the-return medicines, vitamins, and seasoner supplements. Sildenafil citrate does non protect you or your spouse from acquiring sexually transmitted diseases, buy Rhino online including HIV—the virus that causes AIDS.