Stored Red Blood Cells

Red blood cells (RBCs) are the most common sort of cell discovered within the blood1 and are primarily accountable for delivering oxygen all through the body.2 Over the years, processing and storage methods have dramatically improved the availability of RBCs for transfusion as a life-saving therapy. Oxygen levels in RBCs range between blood donors.5 As soon as blood is collected, RBCs begin to degrade on account of oxidative harm. The images within the determine above are from Bardyn et al., and are component-separated RBC items tested on Day zero that had been examined with a co-oximeter to measure their actual oxygen saturation (%SO2) ranges. That is an example of RBC unit shade as operate of oxygen saturation stage. It is the Hb that gives their red color to the RBCs, the tint of which depends on how many oxygen molecules are bound by the heme group. RBCs with higher oxygen levels seem scarlet (images on the left) and the pictures with decrease oxygen ranges appear darker in color.



What’s going on within the bag during storage? See a depiction of the degradation process that happens during RBC storage and the way it impacts the main capabilities of RBCs within the 3D animation below. Dean L. Chapter 1: Blood and the cells it accommodates. Blood Groups and Red Cell Antigens. Yoshida T, Prudent M, D’Alessandro A. Red blood cell storage lesion: causes and potential clinical penalties. Dailey JF. Chapter 4: The purple blood cells and oxygen transport. Manley J, eds. In: Dailey’s Notes on Blood. Kor DJ, Van Buskirk C, BloodVitals wearable and Gajic O. Red blood cell storage lesion. Bosnian Journal of Basic Medical Sciences. Yoshida T, Whitley PH, Rugg N, et al. Oxygen saturation of collected rbc products is donor dependent. Abstract presented at: The Association for the Advancement of Blood & Biotherapies; October 19-22, BloodVitals SPO2 2019; San Antonio, TX. Orlov D and Karkouti K. The pathophysiology and consequences of red blood cell storage. Yoshida T, Shevkoplyas SS. Anaerobic storage of red blood cells. Mustafa I, Al Marwani A, Nasr KM, Kano NA, and Hadwan T. Time dependent assessment of morphological changes: leukodepleted packed purple blood cells saved in SAGM. DeSantis SM, Brown DW, Jones AR, et al. Characterizing purple blood cell age exposure in massive transfusion therapy: the scalar age of blood index (SBI). DePew S, Marques M, Patel R, et al. Estimating oxidative stress burden of multiple blood transfusions in trauma patients. Bardyn M, Martin A, Dögnitz N, et al. Oxygen in red blood cell concentrates: influence of donors’ traits and blood processing.



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